CMIS APIs are available in different languages. I found .NET, JAVA and PHP implementations. Since a few days there is also an API for Python available.

This library has been developed by Jeff Pott. Jeff is the author of the famous book “Alfresco Developer Guide”.

I’ve started a new project on Google Code called cmislib. It is an interoperable client library for CMIS in Python that uses the Restful AtomPub Binding of a CMIS provider to perform CRUD and query functions on the repository.

He tests his library against the Alfresco CMIS repository.
Check his blog post to get further details about this Python library.